稲垣　匡子 (イナガキ　キョウコ)

研究者情報

学位

• 博士（医学）
• 農学修士
• 農学学士

J-Global ID

• 200901086797054062

研究キーワード

• 消化管免疫、がん、肥満、炎症   Mucosal Immunology   

研究分野

• ライフサイエンス / 免疫学

経歴

• 国立国際医療研究センター研究所
• 生理学研究所
• 琉球大学
• 宮崎大学医学部Faculty of Medicine
• 九州大学生体防御医学研究所

学歴

•         -   広島大学   生物生産学部   生物生産学科
•         -   名古屋大学   医学系研究科   免疫学

所属学協会

• 日本栄養・食糧学会   日本分子生物学会   日本生理学会   日本肥満学会   日本食品免疫学会   日本免疫学会   

研究活動情報

論文

• Dietary Fat-Accelerating Leptin Signaling Promotes Protumorigenic Gastric Environment in Mice.

  Arita S; Ogawa T; Murakami Y; Kinoshita Y; Okazaki M; Inagaki-Ohara K

  Nutrients 11 9 2019年09月 [査読有り]
  
• High-fat-diet-induced modulations of leptin signaling and gastric microbiota drive precancerous lesions in the stomach.

  Arita S; Inagaki-Ohara K

  Nutrition (Burbank, Los Angeles County, Calif.) 67-68 110556  2019年07月 [査読有り]
  
• Gastric Leptin and Tumorigenesis: Beyond Obesity.

  Inagaki-Ohara K

  International journal of molecular sciences 20 11 2019年05月 [査読有り]
  
• Subcutaneously administered adrenomedullin exerts a potent therapeutic effect in a murine model of ulcerative colitis.

  Kinoshita Y; Arita S; Murazoe H; Kitamura K; Ashizuka S; Inagaki-Ohara K

  Human cell 32 1 12 - 21 2018年10月 [査読有り]
  
• Antagonizing effect of CLPABP on the function of HuR as a regulator of ARE-containing leptin mRNA stability and the effect of its depletion on obesity in old male mouse

  Nishino, Tasuku; Matsunaga, Ryota; Jikihara, Hiroshi; Uchida, Moe; Maeda, Akane; Qi, Guangying; Abe, Takaya; Kiyonari, Hiroshi; Tashiro, Satoshi; Inagaki-Ohara, Kyoko; Shimamoto, Fumio; Konishi, Hiroaki

  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1861 11 1816 - 1827 ELSEVIER SCIENCE BV 2016年11月 [査読有り]
  
• Antagonizing effect of CLPABP on the function of HuR as a regulator of ARE-containing leptin mRNA stability and the effect of its depletion on obesity in old male mouse.

  Nishino T; Matsunaga R; Jikihara H; Uchida M; Maeda A; Qi G; Abe T; Kiyonari H; Tashiro S; Inagaki-Ohara K; Shimamoto F; Konishi H

  Biochimica et biophysica acta 1861 11 1816 - 1827 2016年11月 [査読有り]
  
• High-fat diet feeding promotes stemness and precancerous changes in murine gastric mucosa mediated by leptin receptor signaling pathway

  Seiya Arita; Yuta Kinoshita; Kaori Ushida; Atsushi Enomoto; Kyoko Inagaki-Ohara

  ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 610 16 - 24 2016年11月 [査読有り]
  
• Leptin receptor signaling is required for high-fat diet-induced atrophic gastritis in mice

  Kyoko Inagaki-Ohara; Shiki Okamoto; Kazuyo Takagi; Kumiko Saito; Seiya Arita; Lijun Tang; Tetsuji Hori; Hiroaki Kataoka; Satoshi Matsumoto; Yasuhiko Minokoshi

  NUTRITION & METABOLISM 13 7  2016年02月 [査読有り]
  
• Chemokine Receptor CCR8 Is Required for Lipopolysaccharide-Triggered Cytokine Production in Mouse Peritoneal Macrophages

  Tomoyuki Oshio; Rei Kawashima; Yuki I. Kawamura; Teruki Hagiwara; Noriko Mizutani; Toshihiko Okada; Takeshi Otsubo; Kyoko Inagaki-Ohara; Akihiro Matsukawa; Tatsuya Haga; Shigeru Kakuta; Yoichiro Iwakura; Seijiro Hosokawa; Taeko Dohi

  PLOS ONE 9 4 e94445  2014年04月 [査読有り]
  
• SOCS, inflammation and metabolism

  INAGAKI-OHARA Kyoko

  J. Mol. Biochem. 3 85 - 96 2014年 [査読有り]
  
• Enhancement of leptin receptor signaling by SOCS3 deficiency induces development of gastric tumors in mice

  K. Inagaki-Ohara; H. Mayuzumi; S. Kato; Y. Minokoshi; T. Otsubo; Y. I. Kawamura; T. Dohi; G. Matsuzaki; A. Yoshimura

  ONCOGENE 33 1 74 - 84 2014年01月 [査読有り]
  
• TWEAK/Fn14 pathway promotes a T helper 2-type chronic colitis with fibrosis in mice

  A. Son; T. Oshio; Y. I. Kawamura; T. Hagiwara; M. Yamazaki; K. Inagaki-Ohara; T. Okada; P. Wu; M. Iseki; S. Takaki; L. C. Burkly; T. Dohi

  MUCOSAL IMMUNOLOGY 6 6 1131 - 1142 2013年11月 [査読有り]
  
• SOCS, inflammation, and cancer.

  INAGAKI-OHARA Kyoko

  JAKSTAT 2 3 e24053  2013年07月 [査読有り]
  
• Adrenomedullin as a Potential Therapeutic Agent for Inflammatory Bowel Disease

  Shinya Ashizuka; Haruhiko Inatsu; Kyoko Inagaki-Ohara; Toshihiro Kita; Kazuo Kitamura

  CURRENT PROTEIN & PEPTIDE SCIENCE 14 4 246 - 255 2013年06月 [査読有り]
  
• Microbiota-derived lactate accelerates colon epithelial cell turnover in starvation-refed mice

  Toshihiko Okada; Shinji Fukuda; Koji Hase; Shin Nishiumi; Yoshihiro Izumi; Masaru Yoshida; Teruki Hagiwara; Rei Kawashima; Motomi Yamazaki; Tomoyuki Oshio; Takeshi Otsubo; Kyoko Inagaki-Ohara; Kazuki Kakimoto; Kazuhide Higuchi; Yuki I. Kawamura; Hiroshi Ohno; Taeko Dohi

  NATURE COMMUNICATIONS 4 1654  2013年04月 [査読有り]
  
• Interleukin-17A is involved in enhancement of tumor progression in murine intestine

  Kiyotetsu Oshiro; Hideyasu Kohama; Masayuki Umemura; Catherine Uyttenhove; Kyoko Inagaki-Ohara; Takeshi Arakawa; Mamoru Harada; Susumu Nakae; Yoichiro Iwakura; Tadashi Nishimaki; Goro Matsuzaki

  IMMUNOBIOLOGY 217 1 54 - 60 2012年01月 [査読有り]
  
• Interleukin-13 Damages Intestinal Mucosa via TWEAK and Fn14 in Mice-A Pathway Associated With Ulcerative Colitis

  Rei Kawashima; Yuki I. Kawamura; Tomoyuki Oshio; Aoi Son; Motomi Yamazaki; Teruki Hagiwara; Toshihiko Okada; Kyoko Inagaki-Ohara; Ping Wu; Suzanne Szak; Yutaka J. Kawamura; Fumio Konishi; Oki Miyake; Hideaki Yano; Yukio Saito; Linda C. Burkly; Taeko Dohi

  GASTROENTEROLOGY 141 6 2119 - U266 2011年12月 [査読有り]
  
• γδ T cells play a protective role during infection with Nippostrongylus brasiliensis by promoting goblet cell function in the small intestine.

  INAGAKI-OHARA Kyoko

  Immunology 134 4 448 - 458 2011年12月 [査読有り]
  
• An enzymatic photometric assay for 2-deoxyglucose uptake in insulin-responsive tissues and 3T3-L1 adipocytes

  Kumiko Saito; Suni Lee; Tetsuya Shiuchi; Chitoku Toda; Masahiro Kamijo; Kyoko Inagaki-Ohara; Shiki Okamoto; Yasuhiko Minokoshi

  ANALYTICAL BIOCHEMISTRY 412 1 9 - 17 2011年05月 [査読有り]
  
• An enzymatic photometric assay for 2-deoxyglucose uptake in insulin-responsive tissues and 3T3-L1 adipocytes.

  Kumiko Saito; Suni Lee; Tetsuya Shiuchi; Chitoku Toda; Masahiro Kamijo; Kyoko Inagaki-Ohara; Shiki Okamoto; Yasuhiko Minokoshi

  Analytical Biochemistry: Methods in the Biological Sciences Vol.412 No.1 9 - 17 2011年01月 [査読有り]
  
• Interleukin-17A is required to suppress invasion of Salmonella enterica serovar Typhimurium to enteric mucosa

  Hirokazu Mayuzumi; Kyoko Inagaki-Ohara; Catherine Uyttenhove; Yuko Okamoto; Goro Matsuzaki

  IMMUNOLOGY 131 3 377 - 385 2010年11月 [査読有り]
  
• Adrenomedullin treatment reduces intestinal inflammation and maintains epithelial barrier function in mice administered dextran sulphate sodium

  Shinya Ashizuka; Kyoko Inagaki-Ohara; Kenji Kuwasako; Johji Kato; Haruhiko Inatsu; Kazuo Kitamura

  MICROBIOLOGY AND IMMUNOLOGY 53 10 573 - 581 2009年10月 [査読有り]
  
• Increased intestinal endotoxin absorption during enteric nematode but not protozoal infections through a mast cell-mediated mechanism

  Ayman Samir Farid; Fumiko Jimi; Kyoko Nagaki-Ohara; Yoichiro Horii

  SHOCK 29 6 709 - 716 2008年06月 [査読有り]
  
• Intestinal intraepithelial lymphocytes sustain the epithelial barrier function against Eimeria vermiformis infection

  Kyoko Inagaki-Ohara; Fitriya Nurannisa Dewi; Hajime Hisaeda; Adrian L. Smith; Fumiko Jimi; Maki Miyahira; Ayman Samir Farid Abdel-Aleem; Yoichiro Horii; Yukifumi Nawa

  INFECTION AND IMMUNITY 74 9 5292 - 5301 2006年09月 [査読有り]
  
• Suppressor of cytokine signalling 1 in lymphocytes regulates the development of intestinal inflammation in mice

  K Inagaki-Ohara; A Sasaki; G Matsuzaki; T Ikeda; M Hotokezaka; K Chijiiwa; M Kubo; H Yoshida; Y Nawa; A Yoshimura

  GUT 55 2 212 - 219 2006年02月 [査読有り]
  
• Intraepithelial lymphocytes express junctional molecules in murine small intestine

  K Inagaki-Ohara; A Sawaguchi; T Suganuma; G Matsuzaki; Y Nawa

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 331 4 977 - 983 2005年06月 [査読有り]
  
• Mucosal T cells bearing gamma delta T-cell receptor play a protective role in intestinal inflammation

  K Inagaki-Ohara; G Matsuzaki; A Sasaki; Y Nawa; A Yoshimura

  IMMUNOLOGY 2004: GENOMIC ISSUES, IMMUNE SYSTEM ACTIVATION AND ALLERGY 173 2 485 - 489 2004年 [査読有り]
  
• SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses

  Y Seki; H Inoue; N Nagata; K Hayashi; S Fukuyama; K Matsumoto; O Komine; S Hamano; K Himeno; K Inagaki-Ohara; N Cacalano; A O'Garra; T Oshida; H Saito; JA Johnston; A Yoshimura; M Kubo

  NATURE MEDICINE 9 8 1047 - 1054 2003年08月 [査読有り]
  
• Negative regulation of cytokine signaling and inflammatory diseases

  K Inagaki-Ohara; T Hanada; A Yoshimura

  CURRENT OPINION IN PHARMACOLOGY 3 4 435 - 442 2003年08月 [査読有り]
  
• Radiation-induced crypt intestinal epithelial cell apoptosis in vivo involves both caspase-3-dependent and -independent pathways

  K Inagaki-Ohara; N Takamura; S Yada; Z Alnadjim; ED Liu; XH Yu; H Yoshida; TS Lin

  DIGESTIVE DISEASES AND SCIENCES 47 12 2823 - 2830 2002年12月 [査読有り]
  
• SOCS1/JAB is a negative regulator of LPS-induced macrophage activation

  Kinjyo, I; T Hanada; K Inagaki-Ohara; H Mori; D Aki; M Ohishi; H Yoshida; M Kubo; A Yoshimura

  IMMUNITY 17 5 583 - 591 2002年11月 [査読有り]
  
• Effect of the deletion of US2 and US3 from herpes simplex virus type 2 on immune responses in the murine vagina following intravaginal infection

  K Inagaki-Ohara; T Iwasaki; D Watanabe; T Kurata; Y Nishiyama

  VACCINE 20 1-2 98 - 104 2001年10月 [査読有り]
  
• Apoptosis of intestinal intraepithelial lymphocytes induced by exogenous and endogenous glucocorticoids

  S Murosaki; K InagakiOhara; H Kusaka; H Ikeda; Y Yoshikai

  MICROBIOLOGY AND IMMUNOLOGY 41 2 139 - 148 1997年 [査読有り]
  

書籍

• 腸管バリアと寄生虫のせめぎあい

  医学のあゆみ 2004年
• ヘルペスウイルス感染と生体防御

  別冊医学のあゆみ 1999年

作品等

• 腸管寄生虫感染による粘膜損傷と修復における腸管上皮間T細胞の役割解明

  2004年
• 腸管上皮間T細胞による腸管バリア構築機構の解明

  2004年
• Regulation of junctional molecules in intestinal epithelial cells during infection with intestinal nematodes

  2004年
• Role of intestinal intraepithelial lymphocytes to construct epithelial barrier

  2004年

MISC

• IL-13 Induces TWEAK-Dependent Activation of TNF-alpha and Intestinal Epithelial Cell Damage -a Pathway Associated With Ulcerative Colitis

  Taeko Dohi; Rei Kawashima; Yuki I. Kawamura; Tomoyuki Oshio; Motomi Yamazaki; Teruki Hagiwara; Toshihiko Okada; Kyoko Inagaki-Ohara; Suzanne Szak; Ping Wu; Yutaka J. Kawamura; Fumio Konishi; Oki Miyake; Hideaki Yano; Yukio Saito; Linda C. Burkly GASTROENTEROLOGY 142 (5) S346 -S347 2012年05月
• Adrenomedullin treatment reduces intestinal inflammation in mice administered dextran sulphate sodium

  Kazuo Kitamura; Shinya Ashizuka; Kyoko Inagaki-Ohara; Kenji Kuwasako; Johji Kato; Haruhiko Inatsu ENDOCRINE JOURNAL 57 S574 -S574 2010年03月
• Suppressor of cytokine signalling 1 in lymphocytes regulates the development of intestinal inflammation in mice

  K Inagaki-Ohara; A Sasaki; G Matsuzaki; T Ikeda; M Hotokezaka; K Chijiiwa; M Kubo; H Yoshida; Y Nawa; A Yoshimura GUT 55 (2) 212 -219 2006年02月
• Intraepithelial lymphocytes express junctional molecules in murine small intestine

  K Inagaki-Ohara; A Sawaguchi; T Suganuma; G Matsuzaki; Y Nawa BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 331 (4) 977 -983 2005年06月
• The role of p53 and Fas in a model of acute murine graft-versus-host disease

  S Yada; N Takamura; K Inagaki-Ohara; MK O'Leary; C Wasem; T Brunner; DR Green; TS Lin; MJ Pinkoski JOURNAL OF IMMUNOLOGY 174 (3) 1291 -1297 2005年02月
• Chronic intestinal nematode infection induces Stat6-independent interleukin-5 production and causes eosinophilic inflammatory responses in mice

  Y Sakamoto; K Hiromatsu; K Ishiwata; K Inagaki-Ohara; T Ikeda; F Nakamura-Uchiyama; Y Nawa IMMUNOLOGY 112 (4) 615 -623 2004年08月
• Mucosal T cells bearing TCR gamma delta play a protective role in intestinal inflammation

  K Inagaki-Ohara; T Chinen; G Matsuzaki; A Sasaki; Y Sakamoto; K Hiromatsu; F Nakamura-Uchiyama; Y Nawa; A Yoshimura JOURNAL OF IMMUNOLOGY 173 (2) 1390 -1398 2004年07月
• The N-terminal truncated isoform of SOCS3 translated from an alternative initiation AUG codon under stress conditions is stable due to the lack of a major ubiquitination site, Lys-6

  A Sasaki; K Inagaki-Ohara; T Yoshida; A Yamanaka; M Sasaki; H Yasukawa; AE Koromilas; A Yoshimura JOURNAL OF BIOLOGICAL CHEMISTRY 278 (4) 2432 -2436 2003年01月
• Negative regulation of cytokine signaling by CIS/SOCS family Proteins and their roles in inflammatory diseases

  Rev Physiol Biochem Pharmacol 149: 435-442 2003年
• Nagative Regulation of Cytokine Signaling and Inflammatory Diseases

  Current Opinion in Pharmacology 3(4): 435-442 2003年
• Suppressor of cytokine signaling-3(SOCS3) regulates onset and maintenance of type 2 helper T cell mediated allergic responses

  Nature Medicine 9(8): 1047-1054 2003年
• Radiation-induced crypt intestinal epithelial cell apoptosis in vivo involves both caspase-3-dependent and -independent pathways

  K Inagaki-Ohara; N Takamura; S Yada; Z Alnadjim; ED Liu; XH Yu; H Yoshida; TS Lin DIGESTIVE DISEASES AND SCIENCES 47 (12) 2823 -2830 2002年12月
• SOCS1/JAB is a negative regulator of LPS-induced macrophage activation

  Kinjyo, I; T Hanada; K Inagaki-Ohara; H Mori; D Aki; M Ohishi; H Yoshida; M Kubo; A Yoshimura IMMUNITY 17 (5) 583 -591 2002年11月
• Critical involvement of CD40 in protection against herpes simplex virus infection in a murine model of genital herpes

  K Inagaki-Ohara; T Kawabe; Y Hasegawa; N Hashimoto; Y Nishiyama ARCHIVES OF VIROLOGY 147 (1) 187 -194 2002年
• Effect of the deletion of US2 and US3 from herpes simplex virus type 2 on immune responses in the murine vagina following intravaginal infection

  Kyoko Inagaki-Ohara; Takuya Iwasaki; Daisuke Watanabe; Takeshi Kurata; Yukihiro Nishiyama Vaccine 20 (1-2) 98 -104 2001年10月
• IL-7 prevents both caspase-dependent and -independent pathways that lead to the spontaneous apoptosis of i-IEL

  S Yada; H Nukina; K Kishihara; N Takamura; H Yoshida; K Inagaki-Ohara; K Nomoto; T Lin CELLULAR IMMUNOLOGY 208 (2) 88 -95 2001年03月
• p53-dependent radiation-induced crypt intestinal epithelial cells apoptosis is mediated in part through TNF-TNFR1 system

  K Inagaki-Ohara; S Yada; N Takamura; M Reaves; XH Yu; ER Liu; Rooney, I; S Nicholas; A Castro; CF Ware; DR Green; T Lin ONCOGENE 20 (7) 812 -818 2001年02月
• Mitochondrial distribution and function in herpes simplex virus-infected cells

  T Murata; F Goshima; T Daikoku; K Inagaki-Ohara; H Takakuwa; K Kato; Y Nishiyama JOURNAL OF GENERAL VIROLOGY 81 401 -406 2000年02月
• Impaired induction of protective immunity by highly virulent herpes simplex virus type 2 in a murine model of genital herpes

  K Inagaki-Ohara; T Daikoku; F Goshima; Y Nishiyama ARCHIVES OF VIROLOGY 145 (10) 1989 -2002 2000年
• Nucleolar localization of the UL3 protein of herpes simplex virus type 2

  H Yamada; YM Jiang; HY Zhu; K Inagaki-Ohara; Y Nishiyama JOURNAL OF GENERAL VIROLOGY 80 2157 -2164 1999年08月
• Murine model of IgE production with a predominant Th2-response by feeding protein antigen without adjuvants

  K Ito; K Inagaki-Ohara; S Murosaki; H Nishimura; T Shimokata; S Torii; T Matsuda; Y Yoshikai EUROPEAN JOURNAL OF IMMUNOLOGY 27 (12) 3427 -3437 1997年12月
• Potential for involvement of Fas antigen Fas ligand interaction in apoptosis of epithelial cells by intraepithelial lymphocytes in murine small intestine

  K InagakiOhara; H Nishimura; T Sakai; DH Lynch; Y Yoshikai LABORATORY INVESTIGATION 77 (5) 421 -429 1997年11月
• Interleukin-15 preferentially promotes the growth of intestinal intraepithelial lymphocytes bearing gamma delta T cell receptor in mice

  K InagakiOhara; H Nishimura; A Mitani; Y Yoshikai EUROPEAN JOURNAL OF IMMUNOLOGY 27 (11) 2885 -2891 1997年11月
• Fas-mediated cytotoxicity by intestinal intraepithelial lymphocytes during acute graft-versus-host disease in mice

  T Sakai; Y Kimura; K InagakiOhara; K Kusugami; DH Lynch; Y Yoshikai GASTROENTEROLOGY 113 (1) 168 -174 1997年07月
• A thymic hormone protects mice from enteropathy during acute graft-versus-host disease

  K InagakiOhara; T Sakai; G Koya; A Awaya; Y Yoshikai MICROBIOLOGY AND IMMUNOLOGY 41 (11) 883 -889 1997年
• Effects of a nonapeptide thymic hormone on intestinal intraepithelial lymphocytes in mice following administration of 5-fluorouracil

  Kyoko Inagaki-Ohara; Noritada Kobayashi; Hitoshi Nishimura; Tetsu Sakai; Yoshihiro Matsumoto; Kenji Hiromatsu; Akira Awaya; Yasunobu Yoshikai Cellular Immunology 171 (1) 30 -40 1996年07月

共同研究・競争的資金等の研究課題

• 胃粘膜の腸型化における胃レプチンシグナルの役割

  県立広島大学：

  研究期間 : 2017年 -2020年 

  代表者 : 稲垣 匡子
• 胃粘膜恒常性維持における胃レプチンシグナルの役割

  国立国際医療研究センター研究所 県立広島大学：

  研究期間 : 2014年04月 -2017年03月 

  代表者 : 稲垣 匡子
• ＡＭＰキナーゼが消化管粘膜において細胞増殖および極性形成に果たす役割

  生理学研究所 国立国際医療研究センター研究所：

  研究期間 : 2011年04月 -2014年03月 

  代表者 : 稲垣 匡子
• サルモネラ菌感染における腸管上皮バリア維持とサイトカインシグナルのクロストーク

  琉球大学：

  研究期間 : 2008年04月 -2011年03月 

  代表者 : 稲垣 匡子
• 腸管寄生虫感染による粘膜損傷と修復における腸管上皮間T細胞の役割の解明

  研究期間 : 2004年 -2008年
• Regulation of junctional molecules in intestinal epithelial celles during infection with intestinal parasites

  研究期間 : 2004年 -2008年
• 腸管寄生原虫感染におけるE-cadherinを介した腸管上皮バリア構築機構の解明

  宮崎大学：

  研究期間 : 2007年04月 

  代表者 : 稲垣 匡子
• Role of intestinal intraepithelial lymphocytes to construct epithelial barrier

  研究期間 : 2003年 -2005年
• 炎症性疾患の発症およびその制御機構
• Regulation of intlammatory diseases